Radioiodine Therapy (131I) Home A-Z Health Information A-Z Health Library Radioiodine Therapy (131I) Overview Radioiodine therapy uses radioactive iodine (I-131) to target and treat thyroid-related conditions, such as hyperthyroidism (overactive thyroid) and thyroid cancer. Since the thyroid naturally absorbs iodine, the treatment delivers targeted radiation to destroy abnormal thyroid cells, either to reduce thyroid hormone production or eliminate cancerous tissues. Common conditions treated Your doctor may recommend radioiodine therapy for:Hyperthyroidism: To reduce the overproduction of thyroid hormones, often due to conditions like Graves’ disease or hyperactive thyroid nodules.Thyroid Cancer: To destroy any remaining cancerous thyroid tissue after surgery or to treat thyroid cancer that has metastasised to other areas. How is the procedure performed? Radioiodine dose: Radioiodine is usually taken as a pill or liquid, which you will swallow in a single dose. It is tasteless and well-tolerated by the body.Absorption by thyroid: The radioactive iodine is absorbed by your thyroid gland over the next few days to months, when it destroys the targeted thyroid cells and reduces overactivity.Follow-up: You may be asked to come back for follow-up blood tests or scans to assess how well the therapy is working. Duration of the procedure Administration of radioiodine: a few minutes (single dose)Absorption and effect: over days to monthsHospital stay: usually not required, but sometimes a short isolation period may be needed depending on the dose Preparation of the procedure Low-iodine diet: You may be asked to follow a low-iodine diet for 1-2 weeks before treatment to help the thyroid gland absorb the radioiodine more effectively. This involves avoiding foods like dairy products, seafood, iodised salt, and processed foods that contain iodine.Medications: Inform your doctor about any medications you are taking, especially thyroid medications. Some medications may need to be stopped temporarily before treatment.Pregnancy and breastfeeding: Radioiodine therapy is not suitable for pregnant or breastfeeding women. You should avoid trying to conceive for at least 6 months after the treatment, and breastfeeding should be stopped prior to therapy.Plan for isolation: After treatment, you may need to limit close contact with others, especially children and pregnant women, for a few days due to the radiation. The exact duration will depend on the dosage of radioiodine. Post-procedure care and recovery Radiation precautions: After receiving radioiodine therapy, you will emit small amounts of radiation. You need to follow specific safety guidelines for a few days to minimise radiation exposure to others. To protect those around you, follow these precautions for a few days after treatment:Limit close contact: Avoid prolonged physical contact with others, especially, pregnant women and young children.Sleep separately: Sleep in a separate bed, if possible, for a few days.Use separate utensils and dishes: Wash your utensils and dishes separately from others.Flush the toilet twice: After using the bathroom, flush the toilet twice and wash your hands thoroughly.Avoid public places: Stay away from crowded areas and public transportation to reduce exposure to others.Your doctor will guide you on the exact duration based on your dose.Most patients can return to their routine in a few days. Disclaimer: The information in this Health Library is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional with any questions about a medical condition or before starting any treatment. Use of this site and its content does not establish a doctor–patient relationship. In case of a medical emergency, call your local emergency number or visit the nearest emergency facility immediately.