CAR-T Cell Therapy Home Centre of Excellence Haematology, Haemato-Oncology & Bone Marrow Transplantati... CAR-T Cell Therapy Overview Advanced, Personalised Immunotherapy for Complex Blood CancersCAR-T Cell Therapy (Chimeric Antigen Receptor T-cell Therapy) is a highly advanced form of immunotherapy that involves modifying a patient’s own immune cells (T-cells) to recognise and destroy cancer cells more effectively. It is typically recommended for patients with certain blood cancers that are relapsed, refractory, or nonresponsive to conventional treatments. At Sir H. N. Reliance Foundation Hospital, we offer a comprehensive CAR-T Cell Therapy program designed to deliver personalised, high-precision cancer care through advanced cellular engineering and controlled clinical protocols. Request a call back Fill in the details below and our advisor will get in touch with you in the next 24 hours Name * Email * Mobile * Enquire For * Location * I consent to receive communications and share my personal data, as per the Terms & Conditions and Privacy Policy * Captcha Get new captcha! What code is in the image? Enter the characters shown in the image. Conditions We Treat How CAR-T Cell Therapy Works Why Choose Sir H.N. Reliance Foundation Hospital for CAR-T Cell Therapy? The CAR-T Therapy Journey CAR-T Cell Therapy is primarily used for specific types of blood cancers, particularly when standard treatments have not been effective:B-cell Acute Lymphoblastic Leukaemia (ALL)High Grade and low Grade Non Hodgkin’s Lymphoma like Diffuse Large B-cell Lymphoma (DLBCL) and Follicular Lymphoma CAR-T Cell Therapy is a multi-step, highly specialised process that transforms a patient’s immune cells into powerful cancer-fighting agents:Cell Collection (Leukapheresis) T-cells are collected from the patient’s blood through a specialised procedure.Genetic Modification In a laboratory, T-cells are engineered with a chimeric antigen receptor (CAR) that enables them to identify cancer cells.Cell Expansion These modified cells are multiplied to create millions of CAR-T cells.Conditioning Therapy Patients may receive chemotherapy to prepare the body for treatment.Cell Infusion The engineered CAR-T cells are infused back into the bloodstream, where they actively seek and destroy cancer cells.Monitoring & Recovery Patients are closely monitored for response and potential side effects in a controlled clinical setting. Once infused, CAR-T cells can continue to multiply and remain active in the body, providing ongoing immune surveillance against cancer. Indications for CAR-T Cell TherapyCAR-T Cell Therapy is typically considered in the following scenarios:Relapsed or refractory blood cancers like acute Lymphoblastic Leukaemia (ALL) and Non Hodgkin’s Lymphoma. Advanced Cellular Therapy Program Our CAR-T Cell Therapy program is built on cutting-edge cellular and precision medicine principles, enabling personalised treatment tailored to each patient’s disease biology.Specialised Infrastructure & Infection ControlPatients undergoing CAR-T therapy require intensive monitoring and controlled environments. Our facility ensures:Highly controlled, infection-safe treatment zonesStrict aseptic protocols and controlled patient accessMultidisciplinary Expert CareThe program is led by expert haemato-oncologists and supported by a collaborative team of specialists:Critical care and intensivist teamNeurology specialists (for therapy-related neurotoxicity management)Infectious disease expertsSpecialised oncology nursing staffClinical dieticians and rehabilitation expertsSupported by:Advanced transfusion medicine servicesPrecision molecular and genetic diagnosticsComprehensive Safety & Monitoring ProtocolsCAR-T therapy requires vigilant monitoring due to potential immune-related side effects. Our protocols include:Continuous clinical monitoring post-infusionEarly detection and management of cytokine release syndrome (CRS)Neurological assessment and intervention protocolsStrict infection surveillance and control measuresPatient-Centric ExperienceRecognising the complexity of the treatment journey, we provide:Personalised care pathwaysContinuous patient and family counsellingNutritional and psychological supportPremium care environments with close monitoring Evaluation & Eligibility Comprehensive assessment to determine suitability for CAR-T therapyCell Collection Extraction of T-cells through apheresisConditioning Therapy Preparation of the body using chemotherapyCAR-T Cell Infusion Reintroduction of engineered cells into the patient’s bloodstreamMonitoring & Recovery Close observation for response, side effects, and long-term outcomes For More Information Consult our specialists to understand eligibility, treatment pathways, and personalised CAR-T therapy options. FAQs What is CAR-T Cell Therapy? CAR-T Cell Therapy (Chimeric Antigen Receptor T-cell Therapy) is an advanced form of immunotherapy that reprograms a patient's own immune cells to recognize and destroy cancer cells. T-cells are collected from the patient's blood, genetically modified in a laboratory to target specific proteins on cancer cells, and then infused back into the body to fight the disease. Who is eligible for CAR-T Cell Therapy? CAR-T therapy is typically recommended for patients with certain blood cancers that have: Relapsed or refractory blood cancers like acute Lymphoblastic Leukaemia (ALL) and Non Hodgkin’s Lymphoma. How does the CAR-T Cell Therapy process work? The CAR-T treatment process involves several steps:Leukapheresis – T-cells are collected from the patient's bloodGenetic modification – T-cells are engineered in a laboratory to express chimeric antigen receptorsCell expansion – Modified cells are multiplied to create millions of CAR-T cellsConditioning chemotherapy – The patient receives low-dose chemotherapy to prepare the bodyInfusion – CAR-T cells are infused back into the patientThe entire process typically takes 3–6 weeks from cell collection to infusion. Is CAR-T Cell Therapy a one-time treatment? Yes, CAR-T therapy is usually administered as a single infusion. Unlike chemotherapy, which requires multiple cycles, most patients receive one dose of CAR-T cells. However, patients require close monitoring for several weeks after infusion and ongoing follow-up appointments to assess treatment response and long-term outcomes. What are the side effects of CAR-T therapy? CAR-T therapy can cause significant but manageable side effects:Cytokine Release Syndrome (CRS)Fever, chills, and fatigueLow blood pressureDifficulty breathingUsually occurs within the first 1–2 weeksNeurological effects (ICANS)Confusion or difficulty speakingHeadachesTremors or seizures in rare casesOther potential side effectsIncreased risk of infections due to lowered immunityLow blood cell countsFatigue lasting weeks to monthsSpecialized medical teams monitor patients closely and have protocols to manage these side effects effectively. How long is the hospital stay for CAR-T therapy? Hospital stay varies based on individual response:Minimum stay: 7–14 days for monitoring after infusionExtended stay: 3–4 weeks if side effects require managementOutpatient monitoring: Patients typically need to remain near the treatment center for 4 weeks post-infusionYour care team will provide specific guidance based on your treatment plan. What is the success rate of CAR-T Cell Therapy? CAR-T therapy has demonstrated remarkable results in patients with previously untreatable cancers:50–90% of patients with certain blood cancers achieve initial remission30–40% of patients may achieve long-term remission lasting yearsResponse rates vary by cancer type, disease stage, and individual factorsClinical outcomes continue to improve as the technology advances and patient selection criteria are refined. Is CAR-T therapy safe? CAR-T therapy is a highly specialized treatment performed under strict clinical protocols at certified treatment centers. While it carries risks—particularly CRS and neurological effects—these are well-characterized and manageable with current medical interventions.Safety measures include:Continuous monitoring during and after infusionTrained specialists in CAR-T side effect managementStandardized treatment protocolsAccess to intensive care if needed How do I know if CAR-T therapy is right for me? Determining eligibility for CAR-T therapy requires a thorough evaluation. Schedule a consultation with a haemato-oncologist who will assess:Your complete medical historyCurrent disease status and prior treatmentsOverall health and organ functionAvailability of approved CAR-T products for your cancer typeThe care team will discuss potential benefits, risks, and alternative treatment options to help you make an informed decision.